ZnO-NPs as an efficient reusable heterogeneous catalyst for synthesis of 1,4-Dihydropyrimidine derivatives in solvent-free conditions

Document Type : Reasearch Paper

Author

• Kh. Pourshamsian

Department of Chemistry, Tonekabon branch, Islamic Azad University, Tonekabon, Iran.

10.7508/ijnd.2015.06.013

Abstract

An efficient synthesis route to 1,4-dihydropyrimidine derivatives from reaction of divergent aldehydes with ethylacetoacetate and urea under solvent-free conditions by ZnO nanoparticles as a relative in expansive, eco-friendly, easy available, non-volatile, non-explosion, thermally robust, recyclable and easy to handle catalyst at 90°C with excellent yields is described. Unenhanced reaction times, simple reaction protocol and work-up, have been improved synthesis of these materials in the presence of this heterogeneous catalyst.

Keywords

• 1,4-Dihydropyrimidinones
• ZnO Nanoparticles
• Solvent-free conditions
• Heterogeneous catalyst
• H-NMR

---