Response surface strategy in the synthesis of Fe3O4 nanoparticles

Document Type : Reasearch Paper

Authors

• N. Khalighyan ¹
• N. Hooshmand ¹
• N. Razzaghi-Asl ²
• K. Zare ³
• R. Miri ²

¹ Department of Chemistry, Marvdasht branch, Islamic Azad University, Marvdasht, Iran.

² Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

³ Chemistry Department, Shahid Beheshti University, Tehran, Evin, Iran.

10.7508/ijnd.2014.05.001

Abstract

In the present study, Fe₃O₄ super paramagnetic nanoparticles were synthesized via co-precipitation of Fe³⁺ and Fe²⁺ chloride salts in the presence of ammonia Solution. The product was characterized by Fourier Transform Infrared spectroscopy (FT-IR), Transmission Electron Microscopy (TEM), and zeta–potential particle size distributing methods. The synthetic procedure of nano iron oxides were optimized using modern statistical optimization methods. A major bottleneck of common optimization protocols is the variation of just one factor at each trial. In modern optimization protocols (experimental design) a combination of factor levels is considered. In the present study, response surface method (RSM) was applied to optimize the synthetic approach towards Fe₃O₄ nanoparticles. Results indicated the importance of acidity and ferric ion amount in achieving desired Fe₃O₄ nanoparticles.

Keywords

• Synthesis
• Nanoparticle
• Fe3O4
• Optimization
• Experimental Disign

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