Nano Al2O3: An efficient catalyst for the multi-component synthesis of Pyrano [2, 3-d] Pyrimidinone derivatives

Montazeri, N.

doi:10.7508/ijnd.2015.03.008

Nano Al2O3: An efficient catalyst for the multi-component synthesis of Pyrano [2, 3-d] Pyrimidinone derivatives

Document Type : Reasearch Paper

Author

N. Montazeri

Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.

10.7508/ijnd.2015.03.008

Abstract

Pyrano [2,3-d] pyrimidinone derivatives have received considerable interest from the pharmaceutical industry due to their wide range of interesting biological and therapeutic properties. Nano Al₂O₃was found to be a highly efficient solid acid catalyst for the preparation of pyrano [2,3-d] pyrimidinone derivatives from the reaction of barbituric acid, aryl aldehyde and malononitrile. Al₂O₃nanoparticles with the average diameter of 15 nm were used four different contents of 10, 15, 20 and 25 mol%. Present methodology offers several advantages, such as high yields, short reaction time, simple procedure with an easy work-up and mild reaction conditions. The products were obtained in high yields under reflux in H₂O:EtOH (1:1). We believe this applicability of nano Al₂O₃with mentioned advantages makes our method superior over all previous reported methods to the synthesis of pyrano [2,3-d] pyrimidinone derivatives. The structures of the products were characterized by their physical constants and comparison of their melting points with those of authentic samples.

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